The Central Regional Meeting for 2023, hosted by the Detroit Local Section of the ACS, will focus on the chemistry being pursued within the region. In addition to symposia and poster sessions concerning organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and chemical education, some of our other sessions are the circular economy for plastics, sustainability in automobiles, cannabis in undergraduate education, expanding green chemistry in the undergraduate curriculum and research experiences, f-block extravaganza, sustainable and environmentally beneficial polymers, DEI initiatives including social media usage in Industry and Academia, and pollution of the Great Lakes watershed: metals, PFAS, PAH, and other chemical hazards.